Local (but not systemic) photobiomodulation treatment reduces mast cell degranulation, eicosanoids, and Th2 cytokines in an experimental model of allergic rhinitis

A Schapochnik, S Klein, R Brochetti, PT Alonso… - Lasers in Medical …, 2021 - Springer
… ) immediately after the last instillation of OVA (1%) daily for 3 … of molecular mediators, such
as interleukins IL-4, IL-5, and IL-… -4, and increased IL-10 without altering IL-5 or IFN-gamma. It …

[HTML][HTML] Inhibition of allergic response by intranasal selective NF-κB decoy oligodeoxynucleotides in a murine model of allergic rhinitis

JH Wee, YL Zhang, CS Rhee… - Allergy, asthma & …, 2017 - ncbi.nlm.nih.gov
… -related cytokine and inflammatory mediator genes expressions. … were administered via daily
OVA instillation from days 20 to … In the present study, mRNA expression of IL-5 and TNF-α in …

Toll-like receptor 9–dependent interferon production prevents group 2 innate lymphoid cell–driven airway hyperreactivity

CLP Thio, ACY Lai, PY Chi, G Webster… - Journal of Allergy and …, 2019 - Elsevier
… cells (ILC2s) are important mediators of allergic asthma. Bacterial … ILC2-derived IL-13 and
IL-5 contribute to asthma … Mice were tracheotomized, and BALF was collected by instilling 1 mL …

[HTML][HTML] MicroRNA-21 inhibition suppresses alveolar M2 macrophages in an ovalbumin-induced allergic asthma mice model

HY Lee, J Hur, JY Kang, CK Rhee… - Allergy, Asthma & …, 2021 - ncbi.nlm.nih.gov
… Macrophages are innate immune cells that mediate initial … BALF was withdrawn after
instillation of 1 mL of sterile PBS … IL-4, IL-5, and IL-13, and increased IL-12 and IFN-γ after OVA …

IL-22 promotes allergic airway inflammation in epicutaneously sensitized mice

JM Leyva-Castillo, J Yoon, RS Geha - … of Allergy and Clinical Immunology, 2019 - Elsevier
… Cytokine levels in supernatants were measured by means of … Furthermore, instillation of
IL-13 in the airways elicits airway … IFN-γ–regulated proinflammatory mediators. Furthermore, IL-…

[HTML][HTML] Neutralization of interleukin-9 ameliorates symptoms of allergic rhinitis by reducing Th2, Th9, and Th17 responses and increasing the Treg response in a …

ZW Gu, YX Wang, ZW Cao - Oncotarget, 2017 - ncbi.nlm.nih.gov
… reducing the levels of multiple inflammatory mediators therein. … IL-5 can stimulate the
development of eosinophils in the bone … nasal instillation of 100 μg OVA in 20 μL saline per …

Alpha-linolenic acid improves nasal mucosa epithelial barrier function in allergic rhinitis by arresting CD4+ T cell differentiation via IL-4Rα-JAK2-STAT3 pathway

Y Ding, Y Wang, Y Zhang, B Dang, S Hu, C Zhao… - Phytomedicine, 2023 - Elsevier
… significantly reduced the stimulating effect of OVA on IL-4, IL-5… /Th2 ratio, reduce IgE, allergic
mediator levels in NALF, as well … decreased by IL-4 and IL-13 and enhanced by IFN-gamma

Skullcapflavone II attenuates ovalbumin-induced allergic rhinitis through the blocking of Th2 cytokine production and mast cell histamine release

TT Bui, CH Piao, CH Song, OH Chai - International Immunopharmacology, 2017 - Elsevier
… The levels of Th1 cytokines such as IFN-gamma, Th2-related … mast cells release allergic
mediators including histamine, pro… IL-4, IL-5, IL-13 and GATA3 were decreased in the NALF by …

Reproducibility of nasal allergen challenge responses in adults with allergic rhinitis

CT Pantin, T Southworth, K Wetzel… - Clinical Pharmacology …, 2019 - Taylor & Francis
… for IL-5, CXCL8, and CCL11 levels after allergen challenge, … Also, we were not able to
investigate other relevant mediatorsmeasurements after daily instillation of allergen: increased

Inhibition of MicroRNA-21 by an antagomir ameliorates allergic inflammation in a mouse model of asthma

HY Lee, HY Lee, JY Choi, J Hur, IK Kim… - Experimental lung …, 2017 - Taylor & Francis
… is one of the most important mediators of the disease, being … BAL fluid (BALF) was withdrawn
after instillation of 1 mL of … The expression of Th2-associated cytokines (IL-4, IL-5, and IL-13…